Overview
Omics Foundation Models
Preclinical models — cell lines, organoids, xenografts — are indispensable for drug discovery and persistently hard to connect back to patient biology. Subtypes don’t transfer cleanly, drug-response predictions fail in patients, and the gap is structural. RNA1-DA closes it: a single molecular space where clinical tumors and preclinical models can be compared, clustered, and transferred — in both directions.
RNA1 is pre-trained on 180K+ bulk RNA-seq samples; the RNA1-DA domain-adaptation layer deconvolves cancer-cell signal and aligns tumors, cell lines, organoids and xenografts into one embedding — enabling forward and reverse translation across the pre-clinical / clinical gap.